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Awards & Publications

The Co-Founder of MetaKura, Dr. Noel Maclaren has been recognized by numerous awards and distinctions. These include the Juvenile Diabetes Foundation International Award, David Rumbough Scientific Award, from the Juvenile Diabetes Foundation. and the International Scientist Award from the Canadian Diabetes Association. The Best Doctors Group which is affiliated with Harvard University has repeatedly named him one of the Best Doctors in America and he is continually named in Best Doctors of New York.

Areas of Pioneering Research

During his career in research and academic endocrinology, Dr. Maclaren and his colleagues pioneered the use of antibody and genetic markers to identify impending type-1 diabetes among unaffected relatives and the general population. He made discoveries of many disease marker antibodies that appear prior to or coincide with their clinical manifestations of a number of autoimmune endocrine disorders.3 He was a member of the American Diabetes Association committee that first classified diabetes by their causes rather than their treatments. He first conceived the idea for a vaccine for type-1 diabetes, now being developed.4 Dr. Maclaren also identified autoimmune polyglandular syndrome (APS-1)5 currently known worldwide and identified alcohol induced hypoglycemia (low blood sugar) and the mechanism whereby recreational alcohol consumption can lead the shut-down of the liver’s ability to generate glucose needed to fuel brain function.6

2 *Maclaren, N; Lan, M; Coutant, R; Schatz, D; Silverstein, J; Muir,A; Clare-Salzer, M.; She, J-X.; Malone, J; Crockett, S.; Schwartz, S.; Quattrin, T.; DeSilva, M.; VanderVegt, P.; Notkins, A.; Krischer, J.: Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2β predict immune mediated (type1) diabetes in relatives. Journal of Autoimmunity: June 1999; 12(4):279-287. 

3*Chen Q-Y, Nadell D, Zhang X Y, Kukreja A, Huang Y J, Wise J, Svec F, Richards R, Friday K E, Vargas A, Gomez R, Chalew S, Lan M, S, Tomer Y and Maclaren N. (2000) The human leukocyte antigen HLA DRB3*0202/DQA1*0501 haplotype is associated with Graves’ disease in African Americans. J Clinical Endocrinol Metab 85(4) 1545-1549.

Schatz, D., Krischer, J., Horne, G., Riley, W., Spillar, R., Silverstein, J., Winter, W., Muir, A., Derovanesian, D., Shah, S., Malone, J., Maclaren, N.: Islet cell antibodies predict insulin dependent diabetes in U.S. school age children as powerfully as in unaffected relatives. J Clin Invest 1994, 93:2403-2407.

4*Ramiya V, Lan M, Wasserfall C, Notkins A L, and Maclaren N K. (1997). Immunization therapies in the prevention of diabetes. J Autoimmunity 10: 287-292.

5Chen, Q-Y.; Lan, M.; She, J-X.; and Maclaren, N.K. The Gene Responsible for Autoimmune Polyglandular Syndrome Type 1 Maps to Chromosome 21q22.3 in US Patients. J. of Autoimmunity. 11: 177-183, 1998.

6Maclaren, N.; Valman, B.; and Levin, B.:  Alcohol induced hypoglycemia in childhood.  Brit Med J 1, 1970, p. 278280.

Maclaren N K in Expert Committee on the Diagnosis and Classification of Diabetes Mellitus Diabetes Care: 1997: 20 1183-1197

Song,Y-H.; Li,Yangxin,Li.; Maclaren,N.K. The nature of autoantigens targeted in autoimmune endocrine diseases. Immunology Today 1996, 17 (5), 232-238. 

Motagheti R, Gujral S, Sinha AS, Sison C Ten S and Maclaren NK (2007) Insulin like growth factor binding protein one to screen for insulin resistance. Diabetes Technology and Therapeutics 9(1) .

Neufeld, M.; Maclaren, N.; and Blizzard, R.:  Two types of autoimmune Addison’s disease associated with different polyglandular autoimmune (PGA) syndromes.  Medicine 60, 1981, p. 355362.

Dr. Maclaren has authored over 50 medical book chapters devoted to endocrine and metabolic topics and some 300 peer reviewed original publications in the most highly regarded international scientific journals such as the New England Journal of Medicine, Lancet, Cell, Journal of Clinical Investigation, Science, Journal of Endocrinology and Metabolism and Diabetes amongst others. He was featured on the cover of France’s Paris-Match news weekly when he first proposed a diabetes vaccine.